Phil Jones, who impressed in the first leg at the Bernabeu, has been ruled out for United with an ankle injury. Jonny Evans will compete with Rio Ferdinand and Nemanja Vidic for a place in the starting XI, with right-back Rafael asked to perform a marking job on Cristiano Ronaldo. Manager Alex Ferguson has said he is undecided over whether to start Ryan Giggs or bring him off the bench for his 1,000th senior appearance, while fellow veteran Paul Scholes remains unavailable with a knee injury.
Goalkeeper Iker Casillas, who is recovering from a broken left thumb, will not play at Old Trafford, despite being named in Real Madrid’s squad. But Xabi Alonso, who did not play at the weekend, may start despite his long-term groin problem.
Alex Ferguson: “Real have just played two fantastic games against Barcelona and they’re hitting form at just the right time, while we’ve been playing consistently well for quite a while now. It doesn’t get any bigger than this game: two big clubs, two great histories, it’s set up to be a marvellous game and I don’t think it’ll disappoint.”
Jose Mourinho: “I expect United to be very defensive when we have the ball, and to attack strongly when they have it. Even though we’re behind in the tie and have to attack, we’ll also have to defend stoutly. We come here after two important wins, but even coming here after two defeats would make no difference. It’s good to have players happy, with morale high after beating their rivals (Barcelona) twice.”
Real Madrid are one of two Spanish teams to have beaten Manchester United at Old Trafford in the Champions League (Deportivo La Coruña won 3-2, 19 April 2000).
The Red Devils have only lost once in their last 14 Champions League home games (nine wins, four draws), the last one against CFR Cluj during the group stage this season.
The two Champions League encounters between Manchester Utd and Real Madrid at Old Trafford have produced 12 goals.
Lyon were the last team to knock Real Madrid out at the last 16 stage in the Champions League, back in 2009/10 (0-1, 1-1).
Manchester United have conceded three goals in each of their two home games against Real Madrid in the Champions League.
Real Madrid have only won once in their last five away games in England in the Champions League (two draws, two defeats), against Tottenham at White Hart Lane in April 2011.
Real Madrid have only failed to score once in their last 32 Champions League games, against Barcelona in Santiago Bernabeu in April 2011.
Real Madrid have failed to keep a clean sheet in the Champions League this season (10 goals conceded).
Manchester United have had their woodwork rattled six times, the most of any side in the tournament this season.
Real Madrid have had the most shots in this season’s Champions League (154, that’s 56 more than Manchester Utd).
Alex Ferguson has only won twice in his 15 competitive encounters against José Mourinho (seven draws, six defeats).
Only Didier Drogba has scored more headed goals (8) than Cristiano Ronaldo (7) in the Champions League since 2003/04.
Angel Di Maria’s four assists in CL 2012/13 have all been delivered against Manchester teams (3 against City, 1 against United).
Cristiano Ronaldo has scored seven goals in 23 Champions League games at Old Trafford. He has 16 goals in 18 games at the Bernabeu.
Manchester United 21/10, draw 9/4, Real Madrid 13/10