Daniel Sturridge has joined Jermain Defoe and Michael Carrick in pulling out of England’s squad for Wednesday’s prestigious friendly against Brazil.
Liverpool forward Sturridge, 22, joined up with the squad but has been ruled out with a thigh injury.
Tottenham striker Defoe, 30, suffered an ankle injury in a win at West Brom, while Manchester United midfielder Michael Carrick, 31, has a hip injury.
No replacements have yet been named for the 24-man squad.
Defoe’s injury appears the worst and Spurs boss Andre Villas-Boas said: “He rolled his ankle.
“He will have to have a scan to reveal the extent of the injury.
“Hopefully, there is not a lot of ligament damage. If there is, he could be out for two to three weeks.”
Carrick played the full 90 minutes of his side’s win at Fulham on Saturday.
Sturridge was substituted after 90 minutes of Liverpool’s 2-2 draw at Manchester City on Sunday and later joined up with the England squad at St George’s Park before withdrawing on Monday.